Study shows that TPP (tri phenyl phosphate) at 50 µM concentration leads to spontaneous cell death (apoptosis) in mouse liver cells. RNA sequencing showed that TPP particularly modifies gene expression for endoplasmic reticulum stress (errors in protein folding) and autophagy (breakdown of proteins and materials within the cell). pinfa note: the concentrations of TPP tested were e.g. more than four orders of magnitude higher than concentrations of TPP found in human hair, which is considered to concentrate contaminants (70 ng/kg TPP in hair, Chupeau et al., pinfa Newsletter n°140).
“Triphenyl phosphate (TPP) promotes hepatocyte toxicity via induction of endoplasmic reticulum stress and inhibition of autophagy flux”, M. Li et al., Science of the Total Environment 840 (2022) 156461 http://dx.doi.org/10.1016/j.scitotenv.2022.156461